Broad Institute

Accuracy Assessment of Fusion Transcript Detection via Read-Mapping and De Novo Fusion Transcript Assembly-based Methods

**Background**Accurate fusion transcript detection is essential for comprehensive characterization of cancer transcriptomes. Over the last decade, multiple bioinformatic tools have …

B. j. haas

Decoding Human Fetal Liver Haematopoiesis

Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly …

D. m. popescu

Nuclei Multiplexing with Barcoded Antibodies for Single-Nucleus Genomics

Single-nucleus RNA-seq (snRNA-seq) enables the interrogation of cellular states in complex tissues that are challenging to dissociate or are frozen, and opens the way to human …

J. t. gaublomme

STAR-Fusion: Fast and Accurate Fusion Transcript Detection from RNA-Seq

**Motivation:** Fusion genes created by genomic rearrangements can be potent drivers of tumorigenesis. However, accurate identification of functionally fusion genes from genomic …

B. haas