Genentech

SCALLOPS: a scalable, integrated computational framework for Optical Pooled Screens

Optical pooled screens (OPS) link pooled genetic perturbations to high-dimensional image-based phenotypes at scale, but their widespread adoption is hindered by computational …

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Joshua Gould

The Hippo Pathway Is Dysregulated in Cancer-Associated Fibroblasts in Anti–PD-L1–Resistant Cancer

The use of immunotherapy in solid tumors has significantly improved the outcomes and quality of life for patients with cancer. However, a substantial fraction of patients remains …

J. roels

Linking live-cell behavior to transcriptional responses across perturbations using dynamic caging

Single-cell technologies, encompassing molecular, morphological, and functional assays, have emerged as cornerstones of modern biological research and discovery. However, current …

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Brian Orcutt-Jahns