CSEM

Jul 14, 2011·
Dr. Bo Li
Dr. Bo Li
· 1 min read

CSEM (ChIP-Seq multi-read allocation using Expectation-Maximization) is one of the first ChIP-Seq multi-mapping read allocators, which allows multi-reads to be utilized by peak callers.

C++ ChIP-Seq Multi-Read Allocation Expectation-Maximization
Dr. Bo Li
Authors
Dr. Bo Li
Principal Scientist II
Dr. Bo Li is a Principal Scientist at Genentech, Inc. His research focuses on large-scale single-cell genomics data analysis. Before joining in Genentech, he was an Assistant Professor of Medicine at Harvard Medical School and the director of Bioinformatics and Computational Biology at Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital. He received his Ph.D. in computer science from UW-Madison and completed two postdoctoral trainings with Dr. Lior Pachter at UC Berkeley and Dr. Aviv Regev at Broad Institute. He is best known for developing RSEM, an impactful RNA-seq transcript quantification software. RSEM is cited 22,602 times (Google Scholar) and adopted by several big consortia such as TCGA, ENCODE, GTEx and TOPMed.